2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Melanocortin Receptor

Melanocortin Receptor

MC Receptor

Melanocortin Receptor

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The melanocortin (MC) receptors represent a subfamily of G-protein-coupled receptors (GPCRs) where the different subtypes are involved in a wide range of physiological functions such as pigmentation, steroid secretion, energy homeostasis, and food intake. The melanocortin receptor (MCR) family consists of five G-protein-coupled receptors (MC1R-MC5R). MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function.

MCRs are activated by a variety of neuropeptides, termed melanocortins, that include the adrenocorticotropic hormone (ACTH) andα, β and γ-melanocyte-stimulating hormones (MSHs). Melanocortins derive from post-translational processing of the common polypeptide precursor pro-opiomelanocortin, expressed mainly in the hypothalamus and pituitary.

Melanocortin Receptor Isoform Specific Products:

Melanocortin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N2466A
    Melanotan I acetate
    		Agonist
    Melanotan I acetate is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I acetate is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I acetate can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I acetate can be used for sunlight-induced skin cancers research.
    Melanotan I acetate
  • HY-P3553
    Alsactide
    		Agonist
    Alsactide, a heptadecapeptide analogue, is an adrenocorticotropic hormone (ACTH) agonist. Alsactide can be used in research of central nervous system.
    Alsactide
  • HY-P3561
    Agouti-related Protein (AGRP) (83-132) Amide (human)
    		Antagonist
    Agouti-related Protein (AGRP) (83-132) Amide (human) is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the melanocortin-4 receptor (MC4R) to increase food intake.
    Agouti-related Protein (AGRP) (83-132) Amide (human)
  • HY-155189
    IIIM-8
    		Inhibitor
    IIIM-8 is a melanogenesis inhibitor. IIIM-8 inhibits pigment production both in vitro and in vivo without incurring any cytotoxicity in Human Adult Epidermal Melanocytes (HAEM). IIIM-8 can be used for hyperpigmentation disorders research.
    IIIM-8
  • HY-P4985
    γ3-MSH
    γ3-MSH is derived from the N-terminal segment of pro-opiomelanocortin (POMC). γ3-MSH stimulates aldosterone secretion by human adrenal tumor cells in culture.
    γ3-MSH
  • HY-P0252B
    α-MSH free acid
    		Agonist
    α-MSH free acid (α-Melanocyte-Stimulating Hormone free acid) is an MC3R and MC4R agonist with EC50s of 0.16 nM and 5.6 nM, respectively. α-MSH free acid activates cAMP generation at MC3R and MC4R.
    α-MSH free acid
  • HY-B1456AS
    Fenoprofen-13C6 sodium hydrate
    Fenoprofen-13C6 (sodium hydrate) is the 13C labeled Fenoprofen (HY-B1456A). Fenoprofen is a nonsteroidal anti-inflammatory agent (NSAID). Fenoprofen can be used to to relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. Fenoprofen is an allosteric enhancer for melanocortin receptors. Fenoprofen also increases ERK1/2 activation[1][2][3].
    Fenoprofen-<sup>13</sup>C<sub>6</sub> sodium hydrate
  • HY-135014
    Undecylenoyl phenylalanine
    		Antagonist
    Undecylenoyl phenylalanine is an antagonist for α-melanocyte-stimulating hormone (MSH) and β-adrenergic receptor (β-ADR) to reduce the melanogenesis in melanocytes, reduces hyperpigmentation and thus ameliorates melasma lesions and solar lentigines.
    Undecylenoyl phenylalanine
  • HY-P6176
    JLB2-110c
    		Inhibitor
    JLB2-110c activates MCRs receptor (mMC4R EC50 = 0.34 nM) and has a strong in vivo appetite suppressant effect.
    JLB2-110c
  • HY-P3567
    (p-Iodo-Phe7)-ACTH (4-10)
    		Antagonist
    (p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats.
    (p-Iodo-Phe7)-ACTH (4-10)
  • HY-P2113
    ORG-2766
    ORG-2766 is an adrenocorticotropic hormone ACTH 4-9 analog and neurotrophic peptide. ORG-2766 affects behavioral processes such as memory and attention in animals, improving symptoms in rats with experimental allergic neuritis. ORG-2766 has a neuroprotective effect.
    ORG-2766
  • HY-P5248
    Tetrapeptide-1
    		Agonist 99.80%
    Tetrapeptide-1 is a bioactive peptide with antioxidant effect and has been reported used as a cosmetic ingredient.
    Tetrapeptide-1
  • HY-RS08204
    Mc2r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mc2r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc2r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc2r Mouse Pre-designed siRNA Set A
    Mc2r Mouse Pre-designed siRNA Set A
  • HY-N7587
    Chlorophorin
    		Inhibitor
    Chlorophorin is a inhibitor of Melanocortin Receptor. Chlorophorin reduces tyrosinase activity and inhibits a-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells.
    Chlorophorin
  • HY-P1210
    Lys-γ3-MSH(human)
    		Agonist
    Lys-γ3-MSH(human) is a melanocortin peptide derived from the C-terminal of the fragment of pro-opiomelanocortin (POMC). Lys-γ3-MSH(human) potentiates the steroidogenic response of the rat adrenal to adrenocorticotrophin (ACTH). Lys-γ3-MSH(human) is a potent stimulator of lipolysis with an apparent EC50 of 3.56 nM. Lys-γ3-MSH(human) can activate hormone sensitive lipase (HSL) and Perilipin A resulting in lipolysis.
    Lys-γ3-MSH(human)
  • HY-RS08208
    Mc3r Rat Pre-designed siRNA Set A
    		Inhibitor

    Mc3r Rat Pre-designed siRNA Set A contains three designed siRNAs for Mc3r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc3r Rat Pre-designed siRNA Set A
    Mc3r Rat Pre-designed siRNA Set A
  • HY-P1545
    ACTH (1-17)
    		Agonist
    ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM.
    ACTH (1-17)
  • HY-P1208A
    PG-931 TFA
    		Agonist
    PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R(IC50=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo.
    PG-931 TFA
  • HY-P1213A
    JKC363 TFA
    		Antagonist
    JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect.
    JKC363 TFA
  • HY-P3924
    Agouti-Related Protein (54-82) (human)
    		Inhibitor
    Agouti-Related Protein (54-82) (human) (AGRP (54-82) (human)) is an amino-terminal 54-82 fragment of agouti-related protein (AGRP).
    Agouti-Related Protein (54-82) (human)
Cat. No. Product Name / Synonyms Application Reactivity
Melanocortin Receptor Isoform Comparison

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